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What Is Ketamine?
In the 1960s, Belgium developed ketamine as an anesthetic medicine for animals. The FDA approved it as an anesthetic for people in 1970. It was used to treat injured soldiers on the Vietnam War battlefield.
“Someone is trying to jump off a bridge, and they give him ketamine in the ambulance to calm him down, and nine months later, he says, ‘I haven’t felt suicidal for nine months.’
Why is Ketamine Used Medically?
- Ketamine can relieve pain and short-term memory loss (for example, amnesia of a medical procedure).
- In surgery, it is used as an induction and maintenance agent for sedation and to provide general anesthesia.
Pharmacology of Ketamine
it is a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist and blocks HCN1 receptors. However, at higher doses it may also bind to the opioid mu and sigma receptors.
Glutamate, a neurotransmitter (brain chemical), is disrupted by it. Learning, memory, emotion, and pain recognition are all affected by glutamate. As a result, it can increase blood pressure and cause a rapid heart rate.
How Quickly Does Ketamine Work?
- An injection yields a quick response, with effects occurring in seconds to minutes.
- “Snorting” leads to effects in roughly 5 to 15 minutes (this is the most common method of abuse).
- Oral consumption requires between 5 and 30 minutes.
The effects of abuse typically last 1 to 2 hours, but the users judgement, senses and coordination may be affected for up to 24 hours or longer. Sensations the user may seek include floating, stimulation and visual effects.
Ketamine Health Hazards & Side Effects
Abuse of ketamine can be linked with short-term and long-term problems:
- Short-term: Problems with attention, learning, and memory; dreamlike states, hallucinations; sedation; confusion; loss of memory; raised blood pressure; unconsciousness; dangerously slowed breathing.
- Long-term: Ulcers and pain in the bladder; kidney problems; stomach pain; depression; poor memory.
The most common side effects associated with ketamine when used medically are nausea, vomiting, dizziness, diplopia (double vision), drowsiness, dysphoria (unease, restlessness), and confusion. There is also the risk of HIV, hepatitis, and other infectious diseases from shared needles.
In people who are alcoholics or acutely intoxicated with alcohol, ketamine can be fatal. In animal studies, there has been a reported increase in toxicity when ketamine is combined with caffeine.
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